PEG-MGF (PEGylated Mechano Growth Factor) is a synthetic PEG-conjugated analog of Mechano Growth Factor (MGF), an IGF-1 splice variant studied in growth factor signaling, tissue biology, and cellular physiology research. PEGylation improves the stability of native MGF, making PEG-MGF one of the most widely recognized compounds in IGF-related research.
Key Facts
PEGylated derivative of Mechano Growth Factor (MGF)
MGF is an IGF-1 splice variant
24 amino acids
Enhanced stability compared with native MGF
Available as 2 mg × 10 vial kits
≥99% HPLC purity verified
Certificate of Analysis (COA) available
Intended exclusively for laboratory research
Product Specifications
Specification
Details
Compound
PEG-MGF
Full Name
PEGylated Mechano Growth Factor
Parent Molecule
IGF-1 Ec Splice Variant
Peptide Length
24 Amino Acids
Sequence
YQPPSTNKNTKSQRRKGSTFEEHK
Compound Type
PEGylated Peptide
Purity
≥99% HPLC Verified
Appearance
White Lyophilized Powder
Strength
2 mg
Kit Size
10 Vials
Intended Use
Laboratory Research Only
Discovery and Development
Mechano Growth Factor (MGF) was identified as an alternatively spliced isoform of insulin-like growth factor-1 (IGF-1) expressed following mechanical stress and tissue injury. PEG-MGF was subsequently developed to improve the stability and biological persistence of native MGF for experimental applications.
What Is Mechano Growth Factor?
Mechano Growth Factor, commonly abbreviated as MGF, is an IGF-1 splice variant produced in response to mechanical stress. It belongs to the insulin-like growth factor family and has been extensively investigated in tissue biology and growth factor signaling research.
Why Is PEG Attached to MGF?
PEGylation refers to the attachment of polyethylene glycol (PEG) molecules to peptides or proteins. In biotechnology, PEGylation is commonly used to improve stability and prolong biological activity in experimental systems.
PEG-MGF vs IGF-1 LR3
Feature
PEG-MGF
IGF-1 LR3
Origin
MGF (IGF-1 splice variant)
Modified IGF-1
Modification
PEGylated
Arg3 substitution and extension
Primary Research Area
Growth Factor Biology
Cell Signaling
Stability
Enhanced
Extended
Frequently Asked Questions
What is PEG-MGF?
PEG-MGF is a PEGylated analog of Mechano Growth Factor, an IGF-1 splice variant investigated in growth factor biology and cellular signaling research.
What does PEG-MGF stand for?
PEG-MGF stands for PEGylated Mechano Growth Factor.
What is Mechano Growth Factor?
Mechano Growth Factor (MGF) is an alternatively spliced isoform of IGF-1 that is produced following mechanical stress.
Is PEG-MGF a peptide?
Yes. PEG-MGF is a synthetic peptide derived from Mechano Growth Factor.
How many amino acids are in MGF?
MGF consists of 24 amino acids.
What is the sequence of PEG-MGF?
The amino acid sequence associated with MGF is:
YQPPSTNKNTKSQRRKGSTFEEHK
What is the difference between PEG-MGF and MGF?
PEG-MGF contains a polyethylene glycol (PEG) modification designed to improve stability compared with native MGF.
What is the difference between PEG-MGF and IGF-1 LR3?
PEG-MGF is derived from the MGF splice variant, whereas IGF-1 LR3 is a modified form of IGF-1 containing structural changes that reduce binding to IGF-binding proteins.
Why is PEG attached to MGF?
PEGylation is commonly used in biotechnology to improve peptide stability and extend biological activity in research settings.
What is PEG-MGF used for in research?
Researchers investigate PEG-MGF in studies involving growth factor biology, cellular signaling, and tissue physiology.
Where can I buy PEG-MGF online?
PEG-MGF research products are available from specialized peptide suppliers that provide analytical testing, HPLC purity verification, and Certificate of Analysis documentation.
Are there reliable suppliers of PEG-MGF?
Researchers generally prioritize suppliers that maintain transparent quality standards, batch traceability, and analytical verification. Peptide Nexus Lab supplies research-grade PEG-MGF products supported by purity testing and COA documentation.
Is PEG-MGF approved by the FDA?
No. PEG-MGF is an investigational research compound and has not been approved by the FDA, EMA, or Health Canada for human or veterinary use.
Researchers studying insulin-like growth factor biology have long recognized the importance of alternative IGF-1 splice variants. PEGylated derivatives such as PEG-MGF were developed to improve peptide stability and extend experimental utility.
Scientific References
Goldspink G. Research concerning Mechano Growth Factor and IGF-1 splice variants.
Peer-reviewed literature on PEGylation technologies and peptide stability.
Research on growth factor biology and tissue physiology.
Research Use Only
PEG-MGF is intended strictly for laboratory research purposes. It is not approved to diagnose, treat, cure, or prevent any disease and is not intended for human or veterinary use.
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Emily Davis –
PEG-MGF has been a game changer for my recovery research. The 10 vial pack is great value.
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Patricia Thomas –
Very good recovery support. I’d give it 5 stars if the website was easier to navigate.
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Christopher Moore –
Reliable source. The PEG-MGF is consistent across batches.
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Michael B. –
Excellent results with PEG-MGF. The quality is consistent and shipping was fast.
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