MK-677 (Ibutamoren) is a synthetic growth hormone secretagogue supplied in a convenient 10-vial research kit. Widely studied in laboratory settings, MK-677 is researched for its interaction with ghrelin receptors and its role in growth hormone and insulin-like growth factor-1 (IGF-1) signaling pathways. Manufactured to high purity standards, each vial is designed to provide consistency and reliability for scientific research applications.
MK-677, also known as Ibutamoren, is a non-peptide growth hormone secretagogue extensively investigated in endocrine and metabolic research. Through activation of the Growth Hormone Secretagogue Receptor (GHS-R1a), MK-677 has become an important tool for studying growth hormone regulation, insulin-like growth factor-1 (IGF-1) signaling, and age-related changes in endocrine function.
Developed as an orally active small-molecule compound, MK-677 differs from traditional peptide secretagogues while sharing similar areas of scientific interest. This premium research kit is manufactured to rigorous quality standards and undergoes extensive analytical verification to ensure exceptional purity and consistency.
Product Highlights
Available in 2 mg and 5 mg configurations
High-purity research-grade material
≥99% HPLC purity verified
Mass spectrometry identity confirmation
White to off-white powder
Certificate of Analysis (COA) available
Excellent batch-to-batch consistency
Strict quality control procedures
Intended exclusively for laboratory research
What Is MK-677 (Ibutamoren)?
MK-677, commonly referred to as Ibutamoren, is a synthetic non-peptide compound belonging to the growth hormone secretagogue family. Unlike GHRH analogs such as CJC-1295 and Sermorelin, MK-677 acts primarily through activation of the Growth Hormone Secretagogue Receptor-1a (GHS-R1a), also known as the ghrelin receptor.
Because of its unique mechanism and oral activity, MK-677 has become one of the most extensively studied growth hormone secretagogues in endocrine research.
History and Development
MK-677 was originally developed by Merck Research Laboratories during investigations aimed at identifying orally active growth hormone secretagogues. Since its discovery in the 1990s, numerous preclinical and clinical studies have explored its influence on growth hormone and insulin-like growth factor pathways.
Today, MK-677 remains one of the most recognized investigational compounds in the fields of endocrinology, metabolism, and healthy aging research.
Mechanism of Action
MK-677 functions as an agonist of the Growth Hormone Secretagogue Receptor (GHS-R1a). Activation of this receptor has been investigated for its effects on:
Growth hormone signaling
Insulin-like growth factor-1 (IGF-1) pathways
Neuroendocrine regulation
Appetite-associated signaling
Energy metabolism
Cellular communication networks
Healthy aging models
Its long-acting profile and oral activity distinguish MK-677 from peptide-based growth hormone secretagogues.
Primary Areas of Research
Endocrine Function Studies
Researchers utilize MK-677 to investigate physiological mechanisms involved in growth hormone regulation and pituitary signaling.
IGF-1 Signaling Research
Experimental models have explored the relationship between growth hormone secretagogues and insulin-like growth factor pathways.
Metabolic Research
Scientists continue to investigate interactions between endocrine signaling and metabolic homeostasis.
Healthy Aging Models
Age-related changes in hormonal function remain an active field of investigation involving growth hormone secretagogues.
Sleep and Circadian Rhythm Studies
Researchers have explored how endocrine pathways interact with sleep architecture and circadian biology.
Cellular Signaling Pathways
MK-677 is frequently used to investigate receptor activation and intracellular communication mechanisms.
MK-677 vs Ipamorelin
Feature
MK-677
Ipamorelin
Compound Type
Small Molecule
Peptide
Receptor Target
GHS-R1a
GHS-R1a
Administration Characteristics
Orally Active Compound
Peptide Secretagogue
Biological Profile
Long Acting
Short Acting
Research Focus
Endocrine & Metabolic Studies
Pulsatile Signaling Studies
MK-677 vs GHRP-6
Feature
MK-677
GHRP-6
Compound Class
Non-Peptide
Peptide
Receptor Target
GHS-R1a
GHS-R1a
Structure
Small Molecule
Hexapeptide
Activity Profile
Extended
Short Duration
Primary Applications
Endocrine & Aging Research
Endocrine & Appetite Research
Product Specifications
Specification
Details
Compound
MK-677
Alternate Name
Ibutamoren
CAS Number
159752-10-0
Molecular Formula
C27H36N4O5S
Molecular Weight
528.67 g/mol
Compound Type
Non-Peptide Growth Hormone Secretagogue
Purity
≥99% HPLC Verified
Appearance
White to Off-White Powder
Available Strengths
2 mg and 5 mg
Kit Size
10 Vials
Intended Use
Laboratory Research Only
Quality Assurance
Every production batch undergoes comprehensive analytical testing including:
High-performance liquid chromatography (HPLC)
Mass spectrometry identity confirmation
Purity verification
Batch traceability controls
Certificate of Analysis availability
These procedures help ensure exceptional quality and consistency across manufacturing lots.
Storage Guidelines
For optimal stability:
Store material in a cool, dry environment.
Protect from heat, humidity, and direct sunlight.
Maintain sealed containers until use.
Follow established laboratory handling procedures.
Avoid unnecessary exposure to moisture.
Frequently Asked Questions
What does MK-677 stand for?
MK-677 is the developmental code assigned by Merck Research Laboratories. It is also widely known as Ibutamoren.
Is MK-677 a peptide?
No. MK-677 is a small-molecule growth hormone secretagogue rather than a peptide.
Is MK-677 the same as Ibutamoren?
Yes. MK-677 and Ibutamoren refer to the same investigational compound.
What receptor does MK-677 target?
MK-677 primarily interacts with the Growth Hormone Secretagogue Receptor-1a (GHS-R1a), commonly referred to as the ghrelin receptor.
Who developed MK-677?
MK-677 was originally developed by Merck Research Laboratories during the search for orally active growth hormone secretagogues.
What is the difference between MK-677 and GHRP-6?
Although both compounds act through GHS-R1a pathways, MK-677 is a small-molecule secretagogue, whereas GHRP-6 is a synthetic peptide.
Does MK-677 influence IGF-1 signaling?
Researchers have extensively investigated the relationship between MK-677 and insulin-like growth factor-1 pathways in endocrine and metabolic studies.
Is a Certificate of Analysis available?
Yes. Certificates of Analysis are available to verify identity and purity.
Related Research Compounds
Researchers interested in MK-677 frequently investigate:
Smith RG, Van der Ploeg LHT, Howard AD, et al. Discovery and characterization of growth hormone secretagogue receptors.
Murphy MG, Bach MA, Smith RG, et al. Effects of MK-677 on growth hormone physiology.
Nass R, Pezzoli SS, Oliveri MC, et al. Influence of MK-677 on endocrine pathways.
Chapman IM, Bach MA, Van Cauter E, et al. Growth hormone secretagogue investigations.
Peer-reviewed literature concerning GHS-R1a biology and endocrine regulation.
Conclusion
MK-677 (Ibutamoren) is one of the most extensively characterized growth hormone secretagogues in modern research. Through activation of the Growth Hormone Secretagogue Receptor and its influence on endocrine signaling pathways, MK-677 remains a valuable investigational compound for studying metabolism, neuroendocrine biology, growth factor regulation, and healthy aging.
Supported by rigorous quality standards and extensive analytical verification, this premium MK-677 research compound delivers the purity and consistency demanded by advanced laboratories worldwide.
Research Use Only
MK-677 (Ibutamoren) is supplied exclusively for laboratory research purposes. This product is not approved by the FDA, EMA, Health Canada, or any other regulatory authority for human or veterinary use. It is not intended to diagnose, treat, cure, or prevent any disease.
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Helen Adams –
MK-677 is very potent. Great for my research.
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